The 16th China Conference on Knowledge Graph and Semantic Computing (CCKS 2022), organized by the Professional Committee on Language and Knowledge Computing of the Chinese Information Society of China and hosted by Yanshan University, will be held from August 24 to 27, 2022, at Qinhuangdao (Qinhuang International Hotel). The theme of the conference is "Knowledge Graphs Empowering the Digital Economy," aimed at discussing key technologies in language understanding, knowledge acquisition, knowledge integration, and knowledge reasoning during the digital industrialization and industrial digitization process. The goal is to drive innovative applications with knowledge, accelerate the pace of building a digital society, create a favorable digital ecosystem, and contribute to the construction of a digital China.